Studying the prophet’s methods of interaction with his opponents is a need nowadays. Through these procedures, we can be aware of the best ways to penetrate into others hearts and introduce religious ideas (instructions). On the other hand, we can consider Ahle- Ketab including Jews, Christians and some other religious groups like Sabe’in and Magus and pagans including idol and star worshipers, as the most important communities whom the prophet tried to guide. He adopted various procedures to deal with each group and preached them because of their diverse positions, traditions and feelings. Some of these methods include the prophets interaction with the pagans (such as kind treatment, reminding God’s blessings, comparing the idols with Allah, and dispatching letters to the kings) as well as with Ahle- Ketab (such as his reply to religious doubts, confirming the former shari’ahs and prophets, inviting to common ideas, and signing peace treaties.